tuberculosis inhibitor 4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T62087	Tuberculosis inhibitor 4
	Tuberculosis inhibitor 4 (compound 16) is a spirothiazolidinone based on mandelic acid that exhibits potent antimycobacterial action. The inhibitor inhibited 98% of Mycobacterium tuberculosis strain H37Rv at concentratio...
T61411	InhA-IN-4		Antibacterial
	InhA-IN-4 (TU14) is a potent Mycobacterium tuberculosis InhA (enoyl ACP reductase) inhibitor with potential anticancer and antiproliferative activities for the study of Mycobacterium tuberculosis infections.		Antibacterial
T72576	Transketolase-IN-4		Antibacterial
	Transketolase-IN-4 is a transketolase inhibitor with an IC50 value of 3.9 μM.Transketolase-IN-4 inhibited Mycobacterium tuberculosis DXS with an IC50 value of 114.1 μM. Transketolase-IN-4 inhibited the SW620, LS174T, and...		Antibacterial
T63056	Dovramilast	CC-11050	PDE
	Dovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor that reduces the production of pro-inflammatory mediators and cytokines.Dovramilast is used in the study of Mycobacterium tuberculosis infec...		PDE
T67765	MenA-IN-2		Others
	MenA-IN-2 is a potent 1, 4-dihydroxy-2-naphthoate isopentadiene transferase (MenA) inhibitor with an IC50 value of 22 µM for MenA and 10 µM for Mycobacterium tuberculosis (Mtb). The continuous transmission of MenA-IN-2 M...		Others
T3S1612	Kuwanon G	Moracenin B,Kuwanone G	Phosphatase , Antibacterial , Bombesin Receptor , AChR , AChE , Glucosidase
	1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has a...
T61676	4-Piperidinecarboxamide
	4-Piperidinecarboxamide is a mycobacterial aspartyl-tRNA synthetase (AspS) inhibitor and a potential anti-tuberculosis (TB) agent [1].
T39109	ML338	ML338
	ML338 is a selective small molecule inhibitor probe specifically targeting non-replicating Mycobacterium tuberculosis bacilli. It exhibits potent activity against non-replicating M. tuberculosis, with IC90 and IC99 value...
T72300	Mtb-cyt-bd oxidase-IN-4
	Mtb-cyt-bd oxidase-IN-4, an inhibitor of Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase), demonstrates potent activity with an IC50 value of 0.25 μM and inhibits the growth of Mycobacterium tubercul...
T61780	MtTMPK-IN-4
	MtTMPK-IN-4 (compound 2), a para-piperidine, is a highly potent inhibitor of thymidylate kinase (MtTMPK) in Mycobacterium tuberculosis, exhibiting an IC50 value of 6.1 μM. Additionally, it possesses remarkable inhibitory...
T72302	Mtb-cyt-bd oxidase-IN-6
	Mtb-cyt-bd oxidase-IN-6, a potent inhibitor of Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase (MtbCyt-bd Oxidase), exhibits an inhibitory concentration (IC50) of 0.35 μM and effectively suppresses Mtb gr...
T61395	Mt KARI-IN-4
	Mt KARI-IN-4 (compound 5c) is a highly effective inhibitor of Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), demonstrating a Ki value of 5.48 μM. Additionally, Mt KARI-IN-4 displays inhibitory propert...
T62147	DprE1-IN-4
	DprE1-IN-4 is a potent, non-covalent inhibitor of DprE1 (IC50: 0.90 μg/mL). DprE1-IN-4 has acceptable pharmacokinetic properties and has a significant bactericidal effect in a mouse model of acute tuberculosis.
T37880	OPC-167832
	OPC-167832 is a potent and orally active dprE1 Inhibitor with an IC50 of 0.258 μM. OPC-167832 has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis[1]. OPC-16...
T79442	DprE1-IN-7
	DprE1-IN-7 (Compound 64) is a DprE1 inhibitor with potent anti-tuberculosis (TB) activity, demonstrating a minimum inhibitory concentration (MIC) of 1 μM against the Mtb H37Rv strain. It exhibits antimycobacterial effect...